Publications
2025
A potent inhibitor of caspase-8 based on the tetrapeptide sequence of IL-18 reveals shared specificities between inflammatory and apoptotic initiator caspases
C. M. Bourne, N. R. Raniszewski, A. B. Mahale, M. Kulkarni, P. M. Exconde, S. Liu, W. Yost, T. J. Wrong, R. C. Patio, M. Kardhashi, T. Shosanya, M. Kambayashi, B. M. Discher, I. E. Brodsky G. M. Burslem#, C. Y. Taabazuing#
ACS Bio & Med Chem Au (2025) DOI: 10.1021/acsbiomedchemau.4c00146
2024
Distinct sequential death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling
R. S. Wertzman, W. Yost, B. I. Herrmann, C. M. Bourne, D. Sorobetea, C. K. Go, B. S. Saller, O. Groß, P. Scott, A. Rongvaux, C. Y. Taabazuing, I. E. Brodsky#
Science Advances (2024) 10: eadl3629
Inflammatory caspase substrate specificities
P. M. Exconde*, C. M. Bourne*, M. Kulkarni, B. M. Discher, C. Y. Taabazuing#
mBio (2024) 15:7 e02975-23 (Invited Review)
Harnessing pyroptosis for cancer immunotherapy
C. M. Bourne, C. Y. Taabazuing#
Cells (2024) 13(4):346 (Invited Review)
Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS
D. C. Akuma*, K. A. Wodzanowski*, R. S. Wertman*, P. M. Exconde, V. R. Vázquez-Marrero, C. E. Odunze, D. Grubaugh, S. Shin#, C. Y. Taabazuing#, I. E. Brodsky#
eLife (2024) 13: e83725
2023
The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
P. M. Exconde, C. Hernandez-Chavez, C. M. Bourne, R. M. Richards, M. B. Bray, J. L. Lopez, T. Srivastava, M. S. Egan, J. Zhang, S. Shin, B. M. Discher, and C. Y. Taabazuing#
Cell Reports (2023) 42: 113581
Juneteenth in STEMM and the barriers to equitable science
A. Mays, A. Byars-Winston, A. Hinton Jr., A. G. Marshall, A. Kirabo, A. August, B. J. Marlin, B. Riggs, B. Tolbert, C. Wanjalla, C. Womack, C. S. Evans, C. Barnes, C. Starbird, C. Williams, C. Reynolds, C. Y. Taabazuing, C. E. Cameron, D. D. Murray, D. Applewhite, D. J. Morton, D. Lee, D. W. Williams, D. Lynch, D. Brady, E. Lynch, F. U. N. Rutaganira, G. M. Silva, H. Shuler, I. A. Saboor, J. Davis, K. Dzirasa, L. Hammonds-Odie, L. Reyes, M. T. Sweetwyne, M. R. McReynolds, M. D.L. Johnson, N. A. Smith, N. Pittman, O. A. Ajijola, Q. Smith, R. A.S. Robinson, S. C. Lewis, S. A. Murray, S. Black, S. E. Neal, S. Andrisse, S, Townsend, S. M. Damo, T. N. Griffith, W. M. Lambert, W. M. Clemons Jr.
Cell (2023) 186(12):2510-2517
A practical guide to graduate school interviewing for historically excluded individuals
E. Ransey, S. Brookens, H. K. Beasley, A. Marshall, B. J. Marlin, P. Rodriguez-Aliaga, C. A. Headley, C. Wanjalla, A. D. Vazquez, S. Murray, S. Damo, C. Y. Taabazuing# and A. Hinton Jr.#
American Journal of Physiology-Heart and Circulatory Physiology (2023) 324(6)H786-H790
The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases
P. M. Exconde, C. Hernandez-Chavez, M. B. Bray, J. L. Lopez, T. Srivastava, M. S. Egan, J. Zhang, S. Shin, B. M. Discher, and C. Y. Taabazuing#
bioRxiv (2023) p. 2023.02.16.528859
2022
Noncanonical inflammasome assembly requires caspase-11 catalytic activity and intra-molecular autoprocessing
D. C. Akuma, D. Grubaugh, C. E. Odunze, S. Shin, C. Y. Taabazuing, I. E. Brodsky
bioRxiv (2022) p. 2022.09.21.508824
A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome
J. C. Hsiao, A. R. Neugroschl, A. J. Chui, C. Y. Taabazuing, A. R. Griswold, Q. Wang, H. Huang, E. L. Orth, D. P. Ball, G. Hiotis, & D. A. Bachovchin
Journal of Biological Chemistry (2022) 298(7): 102032
Introducing new group leaders: Cornelius Taabazuing
C. Y. Taabazuing
Molecular Cell (2022) 82: 1079—1080
2020
Activation of the CARD8 inflammasome requires a disordered region
A. J. Chui, A. R. Griswold, C. Y. Taabazuing, E. L. Orth, K. Gai, S. D. Rao, D. P. Ball, & D. A. Bachovchin
Cell Reports (2020) 33(2): 108264
The NLRP1 and CARD8 inflammasomes
C. Y. Taabazuing, A. R. Griswold, D.A Bachovchin
Immunological Reviews (2020) 297: 1 – 13 (Invited Review)
Caspase-1 interdomain linker cleavage is required for pyroptosis
D. P. Ball,* C. Y. Taabazuing,* A. R. Griswold, E. L. Orth, S. D. Rao, I. B. Kotliar, L. E. Vostal D. C. Johnson, D.A Bachovchin
Life Science Alliance (2020) 3(3): e202000664
2019
DPP9’s enzymatic activity and not its binding to CARD8 inhibits inflammasome activation
A. R. Griswold, D. P. Ball, A. Bhattacharjee, A. J. Chui, S. D. Rao, C. Y. Taabazuing, D.A Bachovchin
ACS Chemical Biology (2019) 14: 2424−2429
DPP9’s enzymatic activity and not its binding to CARD8 inhibits inflammasome activation
A. J. Chui,* M. C. Okondo,* S. D. Rao,* K. Gai, A. R. Griswold, D. C. Johnson, D. P. Ball, C. Y. Taabazuing, E. L. Orth, B. A. Vittimberga, D. A. Bachovchin
Science (2019) 364(6435): 82 – 85
2018
DPP8/9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia
D. C. Johnson,* C. Y. Taabazuing,* M. C. Okondo, A. J. Chui, S. D. Rao, F.C. Brown, C. Reed, E. Peguero, E. de Stanchina, A. Kentsis, D.A Bachovchin
Nature Medicine (2018) 24(8): 1151 – 1156
Inhibition of DPP8/9 activates the Nlrp1b inflammasome
M. C. Okondo,* S. D. Rao,* C. Y. Taabazuing,* A. J. Chui, S. E. Poplawski, D. C. Johnson, D. A. Bachovchin
Cell Chemical Biology (2018) 25: 262-267
2017
Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages
C. Y. Taabazuing, M. C. Okondo, and D. A. Bachovchin
Cell Chemical Biology (2017) 24: 507-514
The facial triad in the αKG oxygenase Factor Inhibiting HIF (FIH): a role for sterics in linking substrate binding to O2 activation
J. A. Hangasky, C. Y. Taabazuing, C.B. Martin, S. Eron, S. C. Garman, and M. J. Knapp
Journal of Inorganic Biochemistry (2017) 166: 26-33
2016
Substrate promotes productive gas binding in the αKG-dependent oxygenase FIH
C. Y. Taabazuing, J.T. Fermann, S. C. Garman, M. J. Knapp
Biochemistry (2016) 55(2): 277-286
2015
Increased turnover under limiting [O2] by the Thr387 → Ala mutant of the HIF-prolyl hydroxylase PHD2
S. Pektas, C. Y. Taabazuing, M. J. Knapp
Biochemistry (2015) 54(18): 2851-2857
2014
Oxygen sensing strategies in mammals and bacteria
C. Y. Taabazuing, J.A. Hangasky, M. J. Knapp
Journal of Inorganic Biochemistry (2014) 133: 63-72 (Special Issue: “Gas and Redox Sensors”) cover artwork
2013
Imposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases
J. A. Hangasky, C. Y. Taabazuing, M.A. Valliere, and M. J. Knapp
Metallomics (2013) 5(4):287-301 (Themed Issue: “Microbial Metallomics”)
2012
Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model
J. S. Pfingsten, K. J. Goodrich, C. Y. Taabazuing, F. Ouenzar, P. Chartrand and T.R. Cech
Cell (2012) 148(5):922-932
Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)
S. C. Flagg C. B. Martin, C. Y. Taabazuing, B. E. Holmes and M. J. Knapp
Journal of Inorganic Biochemistry (2012) 113(0): 25-30
2011
The second coordination sphere of FIH controls hydroxylation
E. Saban, Y.-H. Chen, J. A. Hangasky, C. Y. Taabazuing, B. E. Holmes and M. J. Knapp
Biochemistry (2011) 50(21): 4733-4740
* Equal Contribution, # Corresponding Author(s)